Applying Nextstrain and iCn3D to Modify and Expand an Existing Activity for Undergraduate Students Characterizing Potential Binding of Antibodies to Mutations in the Pathogens Influenza, Respiratory S

This 16-page article, from the Journal of Advanced Technological Education (J ATE), discusses the study of adapting and expanding the SARS-Cov-2 protocol for antibody biding to various pathogens, including hookworms, RSV, influenza, and Enterovirus D68. Challenges and the opportunities they present for student research are discussed. The article describes "... how modifications to the SARS-Cov-2 protocol designed for SARS-CoV-2 could allow students to investigate the impact of mutations in each of these pathogens when binding to antibodies."

Sections and subsections of the article include: Abstract, Introduction, Methods, Antibody Engineers Hackathon, Using SAbDab to find PDB antibody-pathogen structures, Alignment of sequence data to structure data, Results and Discussion, Hookworm, Influenza, Conclusion, and References.